A team of undergraduates lead by a professor at Cold Spring Harbor demonstrated that many targeted drugs do not work as expected. Target discovery is the pharmaceutical industry's grand challenge.

The pharmaceutical business is perhaps the only industry on the planet, where to get the product from idea to market the company needs to spend about a decade, several billion dollars, and there is about 90% chance of from the time it takes from discovery to a marketed product may take a decade...

If we zoom out of the mundane and take a bird's eye view on life, it is simple. We are born, we grow, we reproduce, we take care of our young while gradually declining, and then we die of a long and terrible or short and not so terrible disease. The millions of years of evolution polished us to accept this paradigm, and the inability to change had made us very content with the situation...